At 10:46 AM reports went in to 911 reporting a vehicle that went over the side on Highway at mile marker 34. Medics from San Bernardino County fire arrived on scene to find one patient with major injuries. California Highway Patrol with the help of Caltrans shut down Highway 330 in Both Directions. Hazmat was called to the scene due to a fuel spill of aprox 80 gallons of diesel fuel. A crew was also requested to clean up major debri and guardrail damage. Multiple heavy duty tow trucks were on scene to recover the vehicle. One reporting party stated the vehicle was serving and brakes were possibly only fire. The patient was transported immediately to a near by trauma center with major injuries. As of Press time highway 330 is still closed in both directions.